New simulation game

Looking to create a new simulation game, it is going to be 2D and rely mainly on the interface (GUI) Which engine is going to be best to do this with? There are loads of different engines and I'm not sure which one will be the best for this genre of game. The graphics quality is not an issue as the graphics are not going to be state of the art anyway.

Any suggestions will be helpful :)
Maybe WxWidgets is an option? I have had thoughts about creating my own simulation game, similar to SimLife, using WxWidgets. I don't have much experience with it but it seems to be relatively easy to create GUIs and it is possible to draw simple graphics with it. I haven't yet measured the performance but I think it will be good enough for my needs, if I ever get started that is (have to finish my other projects first).

http://wxwidgets.org/
Thank you :) I will look into it, from first glances it looks relatively easy to create an interactive GUI.
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